Peptides A-L, by Nevin Pratt
AOD-9604
Weight loss. Bone and cartilage regeneration. Boosts metabolism.
This peptide possibly aids in the prevention and possible treatment of osteoporosis, through direct action on osteoblasts, the cells which build new bone. Also, many clinics combine it with hyaluronic acid injections, because studies show AOD-9604 aids in cartilage regeneration. Among other uses, I recommend this peptide after any PRP, Stem Cells, or Exosomes treatments.
AOD-9604 is the synthesized fragment of human growth hormone (specifically it's the last 15 molecules on the chain). Half life 8-10 hours. AOD-9604 doesn't down-regulate your own endogenous growth hormone production like HGH injections will.
AOD-9604 works best when you are in a calorie deficit. If you have stalled on a GLP-1 (tirzepatide, retatrutide), then AOD-9604 is very effective at breaking the stall. It also helps reduce visceral fat. It combats insulins blockage of your fat cells, making it easier for your body to metabolize fat.
There's a study in Growth Hormone and IGF Research that shows AOD-9604 significantly up-regulates the production of chondrocytes, which are the only cells in your body that can produce cartilage. It has been shown to stimulate the synthesis of cartilage type 2 and aggrecan, which means it might help you avoid a knee replacement!
More info on AOD-9604 can be found here:
https://www.peptidesciences.com/peptide-research/category/aod-9604-articles
That article recommends BPC-157, AOD-9604, and MOTS-c for bone mineral density improvement.
Dosage: 2-3 times per day. 250-600mcg per day. Before eating, and before exercise.
6mg vial, with 3cc BAC = 300mcg per 15 units.
BPC-157
Soft tissue injury repair. Half life 6-8 hrs. Local injection at an injury site is best, but systemic (in the stomache area) works quite well too. People often mix this with TB-500 in the same vial, but I recommend against that. Those two peptides have a different PH and a different half life. Also different optimal dosing schedules. Keep them separate.
A study on using BPC-157 for regeneration can be found here.
Here are a couple of Youtube short videos on it. The first is a Joe Rogan interview, and the second is from a well-known Stanford University professor, Dr. Andrew Huberman:
https://www.youtube.com/shorts/EVejn72GgQo
https://www.youtube.com/shorts/kOUvJVD_78U
Dr. Trevor Bachmeyer calls it a "forever peptide", to be taken daily, and talks extensively about BPC-157 in this video:
https://youtu.be/nRi9GqTfGqY?si=bh2tuRTmX64_awQW
Here are some studies on it:
https://pubmed.ncbi.nlm.nih.gov/34267654/
https://pubmed.ncbi.nlm.nih.gov/40756949/
Dosage: 300mcg to 600mcg daily.
5mg vial with 2cc BAC = 20 units daily = 500mcg/dose.
10mg vial with 2cc BAC = 10 units daily = 500mcg/dose.
10mg vial with 3cc BAC = 10 units for 333mcg.
If your kangaroo can tolerate daily injections, then inject BPC-157 daily, and TB-500 every 3 to 5 days.
Cagrilintide
Weight loss. Operates on different receptors than semaglutide or tirzepatide, so is often stacked with one of them. It activates central amylin receptors to promote satiety, slow gastric emptying, and reduce food intake. Cagrilintide plus semaglutide is called CagriSema. CagriSema is in clinical trial by Novo.
Dosage: Weekly. If stacked with another GLP-1, dose it at about 1/4 the dosage of the other. For example, 8mg of Tirzepatide (or Retatrutide) would be stacked with 2mg of Cagrilintide.
10mg vial with 2cc BAC = 20 units per mg.
12.5mg vial with 2.5cc BAC = 20 units per mg.
Cerebrolysin
Very good at treating Alzheimer's, vascular dementia, stroke, or traumatic brain injury.
Here is a PDF with detailed treatment information:
Typically a 10 ml ampule has 2000mg of Cerebrolysin
IM Dosage: Up to 5 ml* Cerebrolysin can be administered intramuscularly over 3 minutes.
DSIP
A 9-amino acide peptide named by Swiss researchers in the 1970's as "Delta Sleep Inducing Peptide".
DSIP-like material has been found in human brain, plasma, pituitary tissue, and even breast milk, which strongly suggests it’s part of our endogenous physiology. It touches the hypothalamus and pituitary, tweaks stress hormones like ACTH and cortisol, nudges luteinizing hormone and growth hormone, and influences neurotransmitters tied to stress, mood, and pain. Because of all that it does, current researchers seem to refer to it less as a sleep inducer and more as a circadiam rhythm peptide that just happens to help with sleep.
In a chronic pain pilot study, 6 out of 7 patients with things like migraines, psychosomatic pain, and tinnitus-associated pain had significant pain reduction after DSIP therapy. Many of these cases were long-standing and hard to treat. Their depressive symptoms improved alongside the pain.
In small insomnia trials (including a multi-study series by Schneider-Helmert and colleagues), insomniacs given DSIP for a few nights saw complete normalization of sleep patterns. Sleep architecture returned to the range seen in people without insomnia after just four nights of treatment. No next-day hangover and actually better daytime alertness and cognitive performance than placebo.
Dosage: 100-500mcg daily, cycled. 10 days on, 5 days off.
For defense against alzheimer's, stack it with Epitalon and MOTS-C
5mg vial 2cc BAC, 20 units = 500mcg
Epitalon / Epithalon
Increase telomerase length. May help prevent or delay cognitive decline.
25% Lifespan Increase in Rats
Professor Vladimir Dilman and Dr. Ward Dean had co-authored a paper where it was noted by Dilman that in rats, the epithalamine biopeptide increased the lifespan by twenty-five per cent. The paper was entitled The Neuroendocrine Theory of Aging and Degenerative Disease. These Epithalon (Epitalon) studies were later confirmed by Russian Academy Sciences in Moscow Professor Vladimir Khavinson.
Cellular Regeneration
This peptide was discovered that causes telomerase production reactivation in the cells, which allows telomerase to become repaired. This results in the body’s rejuvenation down to the cellular level of your genes. The effects of pineal gland secretion are simulated by this simple tetrapeptide, thus activating the telomerase production in cells.
Senile and Elderly Individuals
The research done by Professor Khavinson was done on senile and elderly individuals that indicated mortality was reduced by almost half when this peptide was administered.
Predictive of Mortality
In elderly subjects, there have been established links between the shortening of a telomere and early mortality. This is how telomeres are considered synonymous to a human being’s biological clock. As these shorten progressively through continuous division of cells, they signal the onset of aging and death, ultimately. It the production of telomeres can be stimulated, cells in the body would not have a limit of time and would then continuously renew and replicate, slowing down the aging effects as a result.
EPITHALON (Epitalon) Effect on Life Span
Research studies prove that telomere lengths actually increase after the administration of the Epithalon (Epitalon) peptide on research subjects. After twelve years of Epithalon (Epitalon) peptide administration, the studies done by scientists proved a thirty to fifty per cent life span increase compared to those that did not receive EPITHALON (Epitalon). This translates to about seven extra years of excellent health and living. Clinical studies only lasted for twelve years and this produced seven extra years.
Dosage: 5-10mg per day, 5 days per week, 2 to 3 weeks per cycle, two or three cycles per year. Any time.
50mg vial with 2cc BAC, 20 units daily = 5mg per dose.
10mg vial with 2cc BAC, 40 units = 2mg
GHK-Cu
GHK-Cu (glycyl-l-histidyl-l-lysine copper) is a naturally occurring copper peptide used primarily for anti-aging, skin regeneration, hair growth, and wound healing. It acts as a signaling molecule to boost collagen and elastin production, reduce inflammation, and improve skin elasticity.
Most often, you’ll find GHK-Cu copper peptides (usually listed in ingredient lists under the name Copper Tripeptide-1) in various cosmetics, with skin care products being some of the most popular use cases. According to a 2018 review, GHK-Cu has demonstrated the ability to:3
- Tighten loose skin
- Reverse age-related skin thinning
- Repair the skin’s protective barrier proteins
- Improve skin firmness and elasticity
- Reduce the appearance of fine lines and wrinkles
- Smooth rough skin
- Stimulate wound healing
- Lessen the appearance of photodamage (sun damage), hyperpigmentation, skin spots, lesions, and more
- Reduce inflammation and damage from free radicals
- Increase hair growth and thickness
Additionally, in research from 2015, the authors noted that GHK-Cu may be able to stimulate collagen, regulate the skin remodeling process, attract immune cells to the site of an injury, and restore “replicative vitality to fibroblasts” (a cell that helps form connective tissue) in patients who’ve undergone radiation therapy for cancer.2 6
Dosage: 1mg to 3mg per day. Any time.
50mg vial with 2.5cc BAC, 10 units daily = 2mg per dose.
80mg vial with 3.5cc BAC, 10 units daily = 2.3mg per dose.
80mg vial with 3cc BAC, 10 units daily = 2.67mg per dose.
100mg vial with 10cc BAC, 10 units daily = 1mg per dose.
100mg vial with 6cc BAC, 10 units daily = 1.67mg per dose.
100mg vial with 5cc BAC, 10 units daily = 2mg per dose.
100mg vial with 3cc BAC, 10 units daily = 3.33mg per dose.
100mg vial with 3.5cc BAC, 10 units daily = 2.85mg per dose.
Glutathione
Antioxidant, detoxification, immune support, reduction of inflamation. Fertility support (increases sperm motility).
Glutathione is a tripeptide, but functionally it’s the master antioxidant and the liver’s lead janitor. Every time you burn fat, process alcohol, or deal with environmental toxins, your liver is cranking through oxidative stress. Without enough glutathione, that stress turns into damage.
It helps clear toxins released by shrinking fat cells, supports mitochondrial function, and keeps your liver membranes, DNA, and enzymes protected while the heavy lifting is done.
Research has shown that natural glutathione levels decline with age, which may increase cellular vulnerability to oxidative stress. Because of these broad protective functions, glutathione is considered essential for sustaining healthy mitochondrial activity and overall cellular homeostasis.
Glutathione works just like American Wellness advertises. However...
I prefer injectable Glutathione over an IV push. It is faster and more convenient to administer, and I can custom tailor the dose (I choose lower dosages done more frequently). It is also cheaper, at only a few dollars per 100mg injection.
I split the 600mg dosage that American Wellness does into 100mg doses, taken as needed, but at most twice weekly for two weeks. If I do a two week schedule, it is a micro-dosing schedule done over two weeks instead of a sudden 600mg blast you would get from American Wellness.
To get a 100mg dose, I mix 3cc of bacteriostatic water with a 600mg vial of Glutathione. This yields a 100mg dose @ 50 units (1/2 cc), pulled via an insulin syringe.
Glutathione injection should be intramuscular (into muscle), whereas most peptides are injected subcutaneous (into fat). I prefer my thigh.
I will use glutathione if I am feeling worn out, sore, and tired, and I can't seem to kick the feeling with more sleep, rest, and/or exercise. I find a glutathione shot to be a better pain reliever and muscle relaxer than Tylenol®, and it wakes me up like a splash of cold water.
Shortly after injection, I get a warm tingly sensation all over my body. Then over the next hour or two, an obvious diminishment of soreness (inflamation), and a wide-awake feeling.
Dosage: 100mg to 200mg per dose, every other day, until max of 600mg to 1200mg. Any time.
600mg vial with 3cc BAC, 50 units per dose = 6 doses of 100mg each.
Ipamorelin
Ipamorelin is a GH releasing peptide. Stimulates Ghrelin (makes you hungry). Half life 2-3 hours. If you instead want a GH releasing peptide that doesn't stimulate ghrelin, use Tesamorelin.
Pair this with CJC-1295. Do not take one without the other.
They are both GH releasers, but along different pathways, and very synergistic with each other.
Dosage:
-
Anti-aging & wellness:
200–300 mcg per day, typically in one or two doses. -
Muscle growth or fat loss:
300–500 mcg per day, with dosing split into AM and PM injections for more stable GH release.
KPV
Skin health, psoriasis, eczema. Wound healing (a bit like BPC-157). Reduces inflamation.
Referred by some doctors as "The Greatest Anti Inflammatory Ever".
Inflamed and damaged tissues are always pumping out "signals" (certain proteins). Those tissues upregulate certain transporters and exhibit increased vascular permeability. In other words, the inflamed tissue is screaming with biochemical distress signals. KPV is drawn to those areas like a magnet, and in doing so, finds and targets the inflamed tissue specifically, regardless of where you initially injected the KPV. Healthy normal tissue doesn't even see the KPV, while the damaged tissue is flooded with it.
A Journal of Pharmacology in Experimental Therapeutics study used a model with two groups of mice with Colitis. One group was given subq injections of KPV, while the control group got Saline injections. The KPV group had dramatic reductions of the disease, and inspection of the colon tissue showed massive protection, with no inflammatory cells, and almost zero ulceration. Also showed reduced clinical severity of arthritis, and CT scans showed profound reduction in bone erosion.
Helps with psoriasis, which is an inflammatory-driven condition that KPV helps reduce or eliminate.
Dosage: 100-500mcg, one to two times per day. Systemically works well, but locally at the problem site is better.
10mg vial with 2.5cc BAC, 10 units = 400mcg.
12.5mg vial with 2.5cc BAC, 10 units = 500mcg.