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  • Injury Repair, by Nevin Pratt

    Disclaimer: Everything here is my opinion only. I am not a medical doctor, and this is not medical advise.  Please consult with your doctor.


    Please read the Overview page before reading this page.  It sets the context for everything else.

    BPC / TB-500:

    The most common peptide used for injury repair is BPC-157, or just simply "BPC".  

    BPC is not a drug.  It is a  type of protein.  Here is the official definition of a peptide, according to the United States NIH (National Institute of Health):

    Peptide: A molecule that contains two or more amino acids (the molecules that join together to form proteins). Peptides that contain many amino acids are called polypeptides or proteins.

    BPC stands for “Body Protection Compound”.  In the elite sports industry, BPC combined with TB-500 (another peptide, also called “Thymosin Beta 4”) together are known as the “wolverine protocol”, so named because of the self-healing that the mythical Marvel Comics character “Wolverine” enjoys.  These two peptides together are known to speed healing, and pretty much every elite athlete all over the world uses this protocol on occasion to speed the healing of sports injuries.

    Google will give the following AI Overview regarding BPC:

    BPC 157, a pentadecapeptide, works by stimulating various cellular processes that promote tissue repair and regeneration, primarily by enhancing cell migration, proliferation, and survival, which can lead to faster healing of wounds, muscle injuries, tendon damage, and other tissue traumas, potentially through mechanisms like activating growth factors and modulating inflammatory responses; however, research is still ongoing and its exact mechanisms are not fully understood. 

    I recommend you Google search “peptide wolverine protocol”, because there is a *huge* amount of information available on it.  I just now did so, and this is what popped up:

    Here are a couple of Youtube short videos on it.  The first is a Joe Rogan interview, and the second is from a well-known Stanford University professor, Dr. Andrew Huberman:

    https://www.youtube.com/shorts/EVejn72GgQo

    https://www.youtube.com/shorts/kOUvJVD_78U

    Here is what Google AI Overview says about possible side effects of BPC:

    Based on current research, BPC 157 appears to have very few reported side effects, with studies showing it to be generally well-tolerated, with minimal local irritation at injection sites being the most common potential issue; however, it's important to note that extensive human clinical trials are limited and it remains an experimental substance with potential unknown long-term effects. 

    One of the possible concerns with it is the fact that BPC is reported to be rather indiscriminate of the type of tissue that it helps to grow and rejuvenate.  Thus, if a person has a cancer tumor, it is thought that it might help the cancer to grow.  There are now animal studies that dispute that.  Rats that were bread for cancer were given BPC, and it actually made the cancer go away.

    BPC is available as an injectable, but also in pill form as well as a topical lotion.  I personally do not have much faith in anything other than the injectable form.  I thin oral only has maybe 60% efficacy compared to injectable, plus has fillers and things that I personally suspect may overwhelm the liver.  I wouldn't do oral.  I would only do injectable.

    Realize also that BPC is not currently regulated by the FDA.  

    BPC has a short half-life, requiring daily dosing.  I used to recommend 5 days on, 2 days off, for four to six weeks, then stop for at least two weeks before beginning another cycle.  The reason was so that your body wouldn't down-regulate, which would make the peptide less effective.  More recent research indicates down-regulation is a non-issue, which leads me to believe daily dosing is fine.

     

    TB-500:

    This synthetic peptide is derived from Thymosin Beta-4, a naturally occurring protein. It is known for its ability to regulate actin, a protein essential for cell movement and structure. TB-500 is theorized to promote cell migration, differentiation, and reduce inflammation, creating a favorable environment for tissue repair.  It is often paired with injectable BPC-157, as part of the "wolverine protocol".

     

    GHK-cU:

    Copper peptide for collagen repair. It's known for its ability to promote cell growth, wound healing, and tissue remodeling, and is often used in skincare products to improve skin texture, firmness, and elasticity. 

    GHK-cU has a short half-life, requiring daily dosing.

     

    Wolverine Protocol:


    BPC-157

    • Dosage: 250–500 mcg, 1–2 times daily

    • Route: Subcutaneous (SQ) injection

    • Purpose: Gut healing, tendon/ligament repair, and reducing inflammation

    TB-500 (Thymosin Beta-4)

    • Dosage: 2–5 mg, 1–2 times per week

    • Route: Subcutaneous (SQ) injection

    • Purpose: Accelerates wound healing, reduces fibrosis, and improves muscle recovery

    GHK-Cu (Copper Peptide)

    • Dosage: 2–5 mg, 1–2 times per week

    • Route: Subcutaneous (SQ) injection

    • Purpose: Skin and tissue regeneration, anti-aging, and wound healing

    Notes: 

    • Many research sources will combine BPC-157 and TB-500 in the same vial.  Those two peptides have a different PH, as well as a different half life.  It seems to me that combining them in the same syringe might degrade both of them, so I wouldn't combine them.  I would keep them separate.

    • If you have a specific injury you want the BPC-157 for, I recommend injecting it locally near the site of the injury.  Otherwise inject BPC systemically (usually around the belly button).

    • TB-500 can be administered systemically and doesn't need to be locally injected.

    • Consider adding a GHRP peptides to the protocol (for growth hormone)

     

    GHRP Peptides:

    Realize that one of the things BPC does is condition the cells to be more receptive to growth hormone, which in turn speeds healing.  But what if you have low growth hormone levels?  This is why you might combine these injury repair peptides with a GHRP peptide.  I have a different section on GHRP peptides, and refer you to that.

    Joint Repair:

    Be sure to also check out this page for more information.